Recurrent Implantation Failure RIF
An estimated total of 18 to 27 percent of women experience recurrent implantation failure, which involves the medical transfer of healthy embryos into the uterine cavity. Scientific research defines recurrent implantation failure as the failure to achieve pregnancy after three high-quality embryos transfers. Even though implantation success rates are relatively skewed, based on individual genetic predisposition, certain specific medical factors can be treated to help increase the likelihood of a patient getting pregnant. RaipurIVF.com ultimately indicates that implantation failure, which occurs after assisted reproduction, can be attributed to a plethora of factors.
The most common reasons for recurrent implantation failure are decreased endometrial receptivity, embryonic defect during transfer and a combination of factors that include suboptimal ovarian stimulation. Some causes of failure are not irreversible with treatment, which means some aspiring parents are forced to seek alternative methods of conception that don’t involve the scientifically advanced test tube phenomenon. A decline in endometrial receptivity involves infectious toxins entering the uterus, thus having a negative impact on embryo implantation. Uterine cavity abnormalities, thin endometrial, altered expression of adhesive molecules and immunological factors are cited as the main causes of decreased endometrial receptivity, according to RaipurIVF.com.
Embryonic defect is a common occurrence that leads to implantation failure. Developing healthy embryos through successful in vitro fertilization does not constitute a high success rate of pregnancy. Embryonic development can be deterred by genetic abnormalities, typically in the X-chromosome. Development can also be hindered from zone pellucid hardening, which disables healthy embryos from effectively penetrating the uterine cavity, therefore leading to the inevitability of failure. Zone thickness has been scientifically proven to result in lower implantation rates. Suboptimal culture conditions are also a prominent cause, which can be improved upon by scientific analysis of individual genetic tendencies.
Chromosomally abnormal embryos fail to implant, regardless of if they display good morphology and strong developmental rates. These types of abnormalities can occur in either male or female genes. RaipurIVF.com states that chromosomal abnormalities, such as translocations, mosaics, inversion, deletion and breakages are at the core of implantation failure in young women. Furthermore, implantation rates steadily decrease for age. For example, a woman over the age of 35 is more likely to endure failure than a woman over the age of 30, but younger than 35. Biological factors, such as age, do not directly relate to genetic abnormalities. However, such factors have a tendency to negatively impact implantation.
Dr. Neeraj Pahlajani at the Test Tube Baby Centre in India states that stress associated with recurrent implantation failure can interfere with ensuing infertility treatments. Psychotherapies have been scientifically tested to reduce anxiety in patients that experience implantation failure, which has the potential to increase the success rate. However, these studies lack substantial efficacy. Biological qualities ultimately cannot be improved through relaxation techniques. The emotional trauma associated with recurrent implantation failure is excruciating for a majority patients forced to encounter its such unfortunate circumstances though. The best method for improving your potential to experience successful implantation is to seek medical care from an experienced fertility specialist, like Dr. Pahlajani.http://www.infertilitysolutions.in/articles/surrogacy.html#surrogacy-pregnancy-parents