Buy Generic Celebrex to get a Relief from Pain

Author: Franklyn Kreiger

About pain

Pain is the most common complaint and reason for everyone to go to a doctor. But, not everyone knows that pain is a protective mechanism or a warning to prevent further tissue injury. Types of pain include Acute Pain, Chronic Pain and Cancer related Pain. Acute Pain is usually of short onset and regularly related with specific injury; lasting from seconds to 6 months Chronic Pain which is continuous or repeated pain that persists beyond the expected curing time and infrequently recognized to a specific cause or injury; lasts for 6 months or longer Cancer related Pain which can be acute or chronic and directly linked with the cancer, a result of chemotherapy or radiation. Classifying pain by location and etiology aids in communication about and treatment of the pain and to predict course of pain and plan effective treatment using this categorization, respectively. Balanced analgesia is a concept of using more than one form of analgesia concurrently to obtain more pain relief with fewer side effects. Two or thr

ee types of agents are used together to maximize pain relief while minimizing the possibly toxic effects of a single agent.

Nonopioid Analgesics (NSAIDs)

These are First class of drugs used for treating pain which treats pain of various etiologies like surgery, trauma, arthritis, and cancer. These have a ceiling effect to analgesia (a state of no pain). Ceiling effect is the state of a dose beyond which no improvement in the analgesic effect is noted and increase in side effects can occur. No tolerance or physical dependence is caused by the use of NSAIDs. Most nonopioids have antipyretic (body temperature reducing) effects and work primarily at the site of injury, or rapidly. NSAIDs block synthesis of prostaglandins which are principal mediators of inflammation and end products of the arachidonic acid pathway which is a cascade of reactions that occur after tissue injury. Examples of NSAIDs are salicylates (aspirin); NSAIDS (ibuprofen, ketorolac, and naproxen); COX-2 inhibitors (celecoxib; generic Celebrex); acetaminophen (paracetamol).

Working of Generic Celebrex

NSAIDs block the COX enzymes reduce prostaglandins due to which Inflammation, pain, and fever are reduced. COX-1 is type of the enzyme produces prostaglandins that support platelets and protect the stomach. Celecoxib (Generic Celebrex), blocks COX-2 but little on COX-1, classified as a selective COX-2 inhibitor, causes less bleeding and fewer ulcers.

Dosage and indications

  • Available in a strength of 100mg as capsules.
  • Indicated for:
  • Osteoarthritis (OA) at a dose of 200 mg once daily or 100 mg twice daily.
  • Rheumatoid Arthritis (RA) at a dose of 100 to 200 mg twice daily.
  • Juvenile Rheumatoid Arthritis (JRA) in 2 years and older in a dose of 50 mg and 100 mg twice daily in patients weighing 10-25 kg and more than 25 kg, respectively.
  • Ankylosing Spondylitis (AS) in a dose of 200 mg once daily single dose or 100 mg twice daily. If no effect is observed after 6 weeks, a trial of 400 mg (single or divided doses) can be beneficial.
  • Acute Pain (AP) and Primary Dysmenorrhea (PD) in an initial dose of 400 mg and followed by 200 mg if needed on first day and 200 mg twice daily as needed on consequent days.
  • Familial Adenomatous Polyposis (FAP) in a dose of 400 mg twice daily with food, as an add-on to usual care.

Side effects

Common side effects may include Stomach pain, dyspepsia, and gas, diarrhea, swelling in hands or feet, Dizziness, Rash, Flu symptoms like stuffy nose, sneezing, sore throat.

Serious side effects which require medical assistance include allergic reactions, signs of a heart attack or stroke like chest pain spreading to the jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, and shortness of breath.

Warnings

Serious and possibly lethal cardiovascular (CV) thrombotic events, heart attack, and stroke; particularly in patients with CV disease/risk factors can be caused. Serious fatal gastrointestinal (GI) adverse events; exactly, in those with a previous history of ulcer disease or GI bleeding, and in elderly patients at high risk for GI events can occur with the treatment of Generic Celebrex. Generic Celebrex 100mg tablets should be discontinued if abnormal liver enzymes worsen. Blood pressure should be checked cautiously during treatment with Generic Celebrex. To be used with caution in patients with fluid retention or heart failure, in the elderly, and in patients with impaired renal function, heart failure, liver dysfunction, and those taking anti-hypertensives. Stop Generic Celebrex proximately if serious skin events like allergies, rash, exfoliative dermatitis, Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) occur.