Health Alert: Low Level of Complement Component 3 Is Dangerous

Complement is an innate immune surveillance system in serum and tissue fluid of normal humans and animals. During the activation of the complement system, a variety of biologically active substances can be produced, causing a series of biological effects, thus participating in the body's anti-infection immunity, expanding the immune effect, and regulating the immune response.

Complement component 3 (C3) is an important and large part of serum, which is mainly synthesized by the liver and macrophages, and it plays an active role in the alternative activation pathway and other pathways. C3 is receiving more and more attention in the clinic, for it shows great potential in the diagnosis and treatment of some diseases, and has high clinical applicability.

What are the reasons for the decrease in C3?

1. The ability to synthesize complement decreases. There are many reasons for the decline in complement synthesis ability. But most of them are very common, such as liver disease, including cirrhosis, acute chronic hepatitis, liver necrosis and so on. These liver diseases can affect the ability of complement synthesis to a large extent.
2. The raw materials for the synthesis of complement are insufficient. When malnutrition occurs, the raw materials are insufficient, and thus complement synthesis cannot continue.
3. Too much complement is consumed or lost. Excessive consumption of complement will inevitably lead to complement reducing. Large burns, rheumatoid arthritis, etc. will cause excessive consumption of complement.

What diseases can low level of C3 cause?

After the number of C3 decreased, people may suffer from diseases such as gastritis, hepatitis A, hepatitis B, liver tumor, pancreatic disease. Common clinical conditions include dry and painful eyes, loss of appetite, pain in stomach, fatigue, and insomnia. In severe cases, it may cause myocarditis, myocardial infarction, hepatitis, and cirrhosis.

What should one do if he or she is losing C3?

1. Exercise. Low immunity is probably caused by lack of exercise. To improve immunity, one can start this plan with exercise, which means to develop a reasonable exercise plan and stipulate the daily exercise time, but it should be appropriate, not too much or too little, and never do exercise.
2. Eat more vegetables. Most vegetables contain substances that improve immunity, so it’s a great idea to eat more vegetables during meals, but the vegetables should not be overcooked, in case the nutrients are destroyed.
3. Take drugs. If it’s necessary, take some drugs that help improve immunity, but it’s worth noting that always follow the doctors’ advice.

C3 is an important substance in the complement system. It plays a major role in maintaining the balance of the internal environment. There are many reasons for the decrease in C3. If there is a serious situation, it is necessary to go to the hospital for examination.

With years of experience and a team of skillful experts, Creative Biolabs is able to provide advanced complement therapeutic and drug discovery services of C3-target of complement system for diseases including systemic lupus erythematosus, endotoxin shock, and membranoproliferative glomerulonephritis.