Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 R

Scientists from the University of Sheffield reveals the effect of common gene targeting role reversal induced Parkinson disease mutations related research, published in the International Journal of Nature Communications. The name is a mutation in the LRRK2 gene causes the individual with the risk of Parkinson disease, however, the mechanism is not clear.

Scientists from the University of Sheffield reveals the effect of common gene targeting role reversal induced Parkinson disease mutations related research, published in the International Journal of Nature Communications. The name is a mutation in the LRRK2 gene causes the individual with the risk of Parkinson disease, however, the mechanism is not clear.

Recently, cancer researchers from the University of Glasgow through research found that melanoma cells may be "follow" the body a naturally occurring molecule trajectory, and this naturally occurring molecules can directly cause diffusion occurs malignant skin cancer, the related research published in the International Journal of PLoS Biology.

At present, the number of patients diagnosed with melanoma is 5 times than 40 years ago. In the UK, every year around 13000 people are diagnosed with the disease, and every year about 2200 people died because of the disease. The development of an effective therapy to inhibit melanoma cell proliferation for effective control of melanoma and treatment of the disease is the key. We can use the clothes in time from the sun or avoid direct sunlight to effectively protect the skin from sunburn, thereby reducing the risk of melanoma.

In this paper, the researchers found that melanoma cells perhaps through a called lysophosphatidic acid (Lpa) molecules to give itself a green light to diffusion, LPA molecules can promote melanoma cell movement in the body diffusion. Through the study of cancer cells and mice, the researchers found that tumor cells can be decomposed by LPA molecules near the environment to open it in the body of the "travel". Once the LPA molecules in the environment surrounding the level drops, the tumor cells will leave the tumor matrix to find contains higher levels of LPA environment.

Unlike other cancers, melanoma cells can spread from the beginning, so once the LPA molecule to give a melanoma cell diffusion direction, they will start in the body diffusion, which means that melanoma is hard to deal with, because its diffusion and deteriorating quickly. Robert Insall said skin cancer cells can open their own light to cause cancer cells to spread. The next step is to reveal how the melanoma cell crushing LPA molecules to open the spread of cancer journey, researchers are still in the beginning of the study, they hope to through further research to help doctors make the reasonable therapy for the treatment of melanoma patients.