Liposomes Extensively Applied for Disease Treatment as Drug Carriers
Recently, WHO has recommended a highly effective new treatment option for visceral leishmaniasis that contains liposomal amphotericin B (LAmB). The previous therapy was injections of an antifungal drug called amphotericin B, which caused several serious side effects, such as the rapid deterioration of the kidneys. Amphotericin B was improved through the liposome-based drug delivery system that suspends the injected amphotericin B in a bubble of fat molecules, leading to better absorption and reduced toxicity. Finally, the new treatment combines injected LAmB and oral miltefosine, which results in a substantial increase in efficacy, with survival rates moving from 55% to 88%.
In addition to toxicity reduction, liposome-based drug delivery systems also enjoy the advantages listed below:
- Improvement and control over pharmacokinetics and pharmacodynamics
- Improving medication effectiveness
- Site avoidance effect
- Liposomes used as target selectors
- Lowering the harmful effects of medications
- Enhanced activity against extracellular pathogens
Indeed, liposomes have attracted much attention from scientists and researchers as potential drug carriers due to their diverse advantages, for example, their high biocompatibility can protect pharmaceuticals from the inactivating effect of external conditions without undesirable side reactions, and they can be loaded with a broad range of drugs, DNA, and diagnostic agents, which inspires an increasing number of the emergence of liposome development research projects.
Currently, liposomes have already been extensively applied for the treatment of some diseases as pharmaceutical drug carriers, including but not limited to cancer, inflammation, infectious diseases (fungi, bacteria, viruses), neuropathic diseases, gene therapeutics, and vaccines. It further demonstrates that the liposome-based drug delivery system has significant commercial potential in developing liposome-based drug delivery technology for drugs and disease treatment.
In addition, researchers should pay much attention to liposome analysis and characterization, one of the critical steps in liposome development. The stability of liposomes, according to the application needs, depends on a number of factors, such as their size, lipid composition, incubation temperature, relative concentration, and lamellar thickness. Therefore, biophysical characterization and analysis are crucial for researchers to better understand their functions.
With years of experience in liposome production and development, Creative Biolabs has established a proprietary liposome platform to meet the rising demand for novel liposome preparations. The application of liposomes to facilitate drug delivery has already had an incredible impact on many biochemical and biomedical areas. The scientists at this company have gleaned extensive experience in all types of lipid nanoparticle systems and are dedicated to helping clients find better and more affordable solutions.