How to choose between tilmicosin and tylosin in veterinary clinical treatment

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Tylosin is a relatively broad-spectrum macrolide antibiotic for animals. It is mainly used in veterinary clinics to treat animal mycoplasma disease and infections caused by some Gram-positive bacteria. Since it was discovered and developed in the 1960s, it has been used in the prevention and treatment of mycoplasma diseases in animals until now. As long as you use the right indications and enough doses, its therapeutic effect on common mycoplasma respiratory diseases in chickens is still good. of.

• It has been used for a long time, especially for its long-term abuse, and its drug resistance problem is becoming more and more serious. After the 1980s, new drug research and development scientists continued to try to develop new macrolide drugs that are more sensitive than tylosin. Through the research on the different components of tylosin, the analysis of its original structure-activity relationship and active groups, they continuously optimized its structure and structure-activity, and invented tilmicol through modern chemical semi-synthesis methods. star.
• Therefore, compared with the original tylosin, the effects of tilmicosin in all aspects have been greatly improved, and now there is a development trend of replacing tylosin. But despite this, tilmicosin still cannot completely replace the drug Tylosin. The reason is that tylosin still has good cost performance in veterinary clinical practice.
• So, in veterinary clinic, how to choose the right one when the two are together?
• First of all, they belong to macrolide anti-mycoplasma drugs, so their anti-bacterial mechanism and anti-bacterial spectrum are basically the same. That is to say, they treat the same kind of respiratory diseases clinically in veterinary medicine, and the mode of action is exactly the same. The price/performance ratio is different.
• Let's do a simple analysis for interested friends from these aspects.
• First, antibacterial activity
• Tylosin is composed of four components A, B, C, and D, of which component A accounts for more than 90% and has the highest antibacterial efficacy. Components B, C, and D account for less than 10%, and their potency is 50%, 70%, and 30% of that of A component, respectively. In aqueous solution, component A will decompose and transform into components B and D with lower antibacterial activity and greater toxicity. Tilmicosin is active with component B. After component B is chemically modified, its antibacterial and anti-mycoplasma activity is significantly enhanced, and its action time in the body is prolonged. Compared with tylosin, it is more suitable for once-a-day administration..
• Second,
• compare the pharmacokinetic parameters of the two in animals with different half-lives. It can be seen that

tilmicosin has improved antibacterial activity compared with tylosin, and the half-life has changed from about two hours to about 30 hours. The time of action and retention in the body is greatly increased, and the antibacterial effect will of course be correspondingly better.

• Third, cost -effectiveness
• In terms of antibacterial activity, tyvanectin is slightly stronger than tilmicosin, both of which are stronger than tylosin; It is about 15 times longer and can be administered once every two days. Therefore, tilmicosin is the most cost-effective.
• Fourth, conclusions
• In poultry and pig farming, macrolide drugs are basically administered orally, so their safety does not need to be considered too much. In terms of antibacterial activity, tilmicosin is stronger than tylosin. For severe drug-resistant mycoplasma infections, it is entirely possible to choose tilmicosin. However, if it is a common infection, the price/performance ratio when choosing Tylosin may be slightly better.

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