How Mesenchymal Stem Cells Provide A Personalized Therapy For Autism

ASD or Autism Spectrum Disorders have their origins in the interaction of environmental factors and genes. Autism is characterized by dysfunctions in communication skills and social interaction, apart from causing stereotypical and repetitive non-verbal and verbal behaviors. These are also some biochemical events associated with the disease. These include oxidative stress, mitochondrial dysfunction, and immune dysregulation, among others. Since there are no drugs as such available for, Autism treatment in India or overseas, research is ongoing for better solutions.

Stem Cell therapy For Autism and ASD

Stem cell therapy is quite promising for a range of neurological and another disease, including Autism. The future of molecular medicine has improved the life of millions of patients worldwide. Among the many different kinds of stem cells used for the purpose of stem cell therapy, the MSCs or Mesenchymal Stem Cells show the best healing properties for treating Autism and many other diseases. MSCs are found in the bone marrow, and they give rise to many different kinds of cells, including the blood, fat, skeletal and vascular cells.

Benefits Of MSC Therapy and Transplantation

1. Autism is characterized by immune disorders. The Mesenchymal Stem Cells that are used for the purpose of stem cell transplantation can help in immuno-suppressive action for long time period. Certain soluble factors provide for this activity. The MSCs can lower the proliferation rate of the T lymphocytes and the killer cells of the immune system. The T lymphocytes are found to secrete the cytokines that are responsible for inflammation. MSCs can also lower the production of the cytokines, thereby reducing inflammation. Patients suffering from Autism Spectrum Disorders show an imbalance in the different types of immune system T cells. MSCs can reduce this immune imbalance.
2. MSCs has a vast expansion potential. They possess high proliferation rates, are genetically stable and can also be easily collected. They are compatible with many different kinds of delivery methods. They also migrate to the damaged sections of the body and stop the release of cytokines, overproduction of which is the cause of inflammation. MSCs differentiate on the basis of cues they obtain from the surrounding cells and tissues and do not cause tumors.
3. The transplantation of the MSCs also promotes synaptic plasticity, rescues Purkinje cells (cells important for transmitting neural signals), and provide functional recovery to the cells.
4. MSCS actually migrate to the site of damage after transplantation and initiate brain repair.
5. MSCs provide for local neural reinnervations, and also integrate within the existing synaptic and neural network, thereby helping in functional recovery.
6. MSCs secrete the growth and the trophic factors. This "paracrine" activity of MSCs provides for the production of certain factors that can activate the endogenous restorative mechanism within all tissues that are injured.

MSCs Therapy NGBSI

NeuroGen Brain and Spine Institute (NGBSI) is located in Mumbai, India. The premier healthcare institute uses stem cell therapy for providing Autism treatment in India. The therapy is based on the obtainment of Mesenchymal Stem Cells from the autologous bone marrow (bone marrow of the patient itself) and their subsequent processing and transplantation. NeuroGen employs an expert team of health care practitioners, including neurosurgeons, an ISO certified and hygienic environment for providing stem cell therapy to patients from across the world. Apart from Autism, NeuroGen also offers stem cell therapy for a range of other incurable health conditions. It provides motor neuron disease stem cell treatment, and molecular stem cell treatment for other disorders including dementia, cerebral palsy, muscular atrophy, spinal cord injury and others.

The author is an expert in the field of stem cell research & therapy. The writer has a flair for writing and she keeps on writing various articles and blogs related to industry.