Next Generation Sequencing Market Projected To Grow With Significant CAGR Over The Forecast Period

Next generation sequencing is the process of sequencing DNA strands similar to the nucleotides in a DNA molecule. Next-generation sequencing is carried by massive parallelization. Next-generation sequencing reduces the requirements for the fragment-cloning method used in sequencing of the genomes by Sanger’s method. Due to high accuracy, precise results, and low cost, and with a low sample, next-generation sequencing is preferred over the Sanger’s method. It is commonly used in oncology studies, biomarker discovery, agricultural and animal research, personalized medicine, and others. In addition, re-sequencing of targets, identification of binding sites of a transcriptional factor, and non-coding RNA expression profiling are other applications of next-generation sequencing.

Increase in the various applications, decreasing the cost of sequencing, increase in gene mapping programs, increasing automation for pre-sequencing programs, and development of personalized medicine which is expected to boost the next generation sequencing market. Moreover, the rise in R&D activities by the market players and drug discovery applications are driving the demand for next-generation sequencing (NGS) market. However, lack of skilled professionals, ethical and legal issues in the interpretation, storage and management of patient data, and high reliability on funding from the government can hamper the next generation sequencing market.

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The next generation sequencing market is divided into-

1. Product and service type

• Pre-sequencing products and services market
• DNA fragmentation, size selection, A-tailing, and end repair
• Library preparation and target enrichment
• Quality control
• Sequencing services market
• Targeted sequencing/gene panels
• RNA-Sequence
• De Novo sequencing
• Exome sequencing
• Chip-Sequence
• Whole-genome sequencing
• Methyl-Sequence
• Others
• Next-generation sequencing, data analysis, storage, and management (Bioinformatics) market
• NGS data analysis software & workbenches
• NGS data analysis services
• NGS storage management and cloud computing solutions

2. Technology

• Ion semiconductor sequencing
• Sequencing by the synthesis (SBS)
• Nanopore sequencing
• Single-molecule real-time (SMRT) sequencing

3. Applications

• Drug discovery
• Diagnostics
• Agriculture and animal research
• Biomarker discovery
• Precision medicine
• Other applications

4. End-users

Biotechnology and Pharmaceutical Companies, research centers, hospitals and clinics, etc.

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And lastly, on the basis of geographical regions into- North America, Asia-Pacific, Latin America, Europe, and the Middle East and Africa. North America holds the largest share due to rise in adoption of next generation sequence, development in the healthcare infrastructure, decrease in the cost, increase in the R&D activities for proteomic and genomic sequence determination. Moreover, most of the end users for clinical and academic use are from the U.S., U.K., and Germany due to presence of universities offering molecular biology course in these regions might bolster the next generation sequencing market. Asia-Pacific is expected to grow at the fastest rate in global next generation sequencing market with owing to increasing investment in development in healthcare expenditure, rising medical awareness in regional population, government funding for translational research, and rising partnerships & agreements among market players. In addition, these countries have less-stringent regulations and data requirements as compared to developed nations; companies find regulatory policies in the Asia-Pacific region to be adaptive and business-friendly. Some of key players in the global next generation sequencing market are Agilent Technologies, Inc. (U.S.), Illumina, Inc. (U.S.), Pacific Biosciences (Danaher Corporation) (U.S.), Thermo Fisher Scientific Inc. (U.S.), Qiagen N. V. (Germany), Beijing Genomics Institute (China), PerkinElmer, Inc (U.S.), F. Hoffmann La Roche AG (Switzerland), Genomatix GmbH (Germany), Oxford Nanopore Technologies (U.K.), and Eurofins Scientific (U.S.) to name a few. In 2017, Illumina’s company with Amgen developed next generation sequencing cancer diagnostic kit which was FDA approved. Similarly, in 2016, Oxford Nanopore Technology launched a USB 3.0 interfaced sequencer interfaced sequencer, the MinION a newer method for multiplexed target enrichment of NGS libraries using the PCR-generated baits.

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Organizations are focusing on the introduction of low-cost sequencing devices in routine medical check-ups. For example, Grail is focusing on the development of a next generation sequencing technology that allows detection of different types of cancer before the symptoms appear. This test is expected to reach the market by 2019. Furthermore, companies are also engaged in producing genomic data by making it available to research laboratories worldwide. Growing partnerships, collaborations, increasing adoption of NGS among research laboratories and academic institutes, and the launch of services and novel products by market players fuel the growth of global next generation sequencing market. Moreover, increase in inclination of drug developers and scientists towards the next generation sequencing technology for the development of personalized medicine is a key driver for the demand of next generation sequencing platforms for gaining insights into the genetic organization.

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