Nimesulide Medicine - Formulation, Properties, Clinical Study and Benefits

Nise 100mg - Nimesulide is an NSAID and a preferential COX II inhibitor developed by DR. Reddy’s with a multi-factorial mode of action. It is a potent analgesic and antipyretic drug. It exhibits potent Anti-Inflammatory action.

Chemical Formulation:

Nimesulide, a wide endorsed medication pain-relieving drug belongs to BCS category II and exhibit low and variable oral bio-availability. Nimesulide with chemical name 4-nitro-2-phenoxymethanesulfoanilide and chemical formula C13H12N2O5S may be a selective Cox-2 anti-inflammatory drug. It is a by-product of p-nitrophenyl methane series sulfa. It is structurally a singular non-steroidal anti-inflammatory drug. It belongs to selective COX-2 inhibitors, with potent analgesic activity.

Properties of Nimesulide:

1. Pharmacokinetics:

It acts as an aggressive inhibitor of histamine discharge in-vivo and in-vitro, subsequently has antihistaminic and anti-allergic properties. Nimesulide does not have noteworthy gastroduodenal symptoms. The beginning of pain relieving and antipyretic activity of oral nimesulide is 1.6– 3.17 h and the term of activity is 10– 12 h.

2. Absorption:

It is well absorbed from the GI tract following oral intake.

3. Pinnacle Plasma Levels:

It’s PPL is mostly 1-3 hours. With offer administrator of 100 mg, the study state is accomplished in 24 to 36 hours.

4. Nimesulide has better canal safety than other NSAIDs. Food, sexual orientation and propelled age have very little effect on Nimesulide pharmacokinetics.

Clinical Study:

Nimesulide's remedial incentive in viable and quickly controlling aggravation and agony is bolstered by indispensable clinical proof. The drug prescribed is supposed to be suitable when the advantage can give to a specific patient exceed the dangers related to its utilization. Hence, a cautious examination of individual hazard factors is along these lines of urgent significance.

Benefits:

• 1. Nimesulide has less gastrointestinal antagonistic impacts than other NSAIDs.

• 2. Nimesulide's benefit-risk ratio is higher when compared to other drugs with comparable safety and tolerability to placebo.

• 3. Its multifactorial method of activity gives it a one of a kind and expansive activity on inflammatory.

• 4. Nimesulide can also be prescribed for sensitive asthmatic patients. It is accounted for to be helpful in calming the symptoms of rhinitis, rhinopharyngitis tubulitis and secretory otitis media with attendant anti-microbial treatment.

• 5. Nimesulide treats intense pain and primary dysmenorrhoea.

• 6. It gives fascinating results by acting quick and fast effects

• 7. No facet effects are observed.

• 8. Nimesulide is used in the treatment of Rheumatic inflammatory disease, degenerative joint disease, alternative chronic joint disorders treatment.

• 9. It treats Musculoskeletal disorders, Thrombophlebitis and Cancer.

• 10. It's demonstrated as a second-line treatment for intense agony, symptomatic treatment of agonizing degenerative joint pains and first dysmenorrhoea.

• 11. It is conjointly used for the treatment of skin-tone, Heart diseases and dry skin.

It is accessible in a very type of structures like tablets, powder for disintegration in water, suppositories, mouth dissolving tablets and topical gel. The most extreme length and a portion of a treatment course with Nimesulide 100mg are 15 days, two times every day, to limit the danger of hepatotoxicity. Thus, Nimesulide Properties and clinical study on Nimesulide reveal the effectiveness of Nimesulide.

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