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Everything you know about trenbolon enanthate!
Posted: Mar 19, 2020
Chemical name: 17beta-hydroxyestra-4,9,11-trien-3-one Molecular
formula trenbolone: C18 H22 O2 Molecular
formula enanthate: C7 H12 O2
Molecular weight trenbolone: 270.37
Molecular weight trenbolone enanthate: 382.55
Ratio of anabolic: androgenic effects: 500 : 500 (relative to nandrolone acetate)
Type of administration: injection Duration of
effect injection: approx. 14 days
Detectability: approx. 6 months
History and general
Trenbolone was first synthesized in 1963 on behalf of the pharmaceutical company Roussel UCLAF. After trenbolone acetate and trenbolone hexahydrobenzyl carbonate, trenbolone enanthate was the third trenbolone ester to be used in bodybuilding. The special thing about trenbolone enanthate is that this active ingredient has never been used in human or veterinary medicine. Instead, it first appeared in the form of products from so-called underground laboratories. The development of this trenbolone ester was probably due to the fact that the hexahydrobenzyl carbonate ester, which was used in the only Trenbolone Depot preparation Parabolan available until then, was a very exotic ester. It was simply cheaper to produce.
The first product that contained Trenbolone Enanthate as an active ingredient was Trenabol by British Dragon. Today there are numerous products from underground laboratories that contain this active ingredient. The significantly more widespread use of trenbolone enanthate compared to trenbolone hexahydrobenzyl carbonate is probably primarily due to the fact that the price of trenbolone enanthate as a raw material is only about a third of the price of trenbolone hexahydrobenzyl carbonate.
Medical application area
Trenbolone enanthate is an active ingredient that is only available in the form of underground products. As already mentioned, it was never used in the medical field.
Structure and special properties
The active ingredient trenbolone belongs to the family of 19-nor steroids. It lacks the methyl group typical of testosterone derivatives at position 19. Trenbolone differs from the structurally related 19-nor steroid nandrolone by an additional double bond at positions 9 and 11. The 3 conjugated double bonds of the trenbolone molecule are called the tried one system and the prefix "Tren" Trenbolon is nothing more than an abbreviation for "Tri-en".
In the case of trenbolone enanthate, an enanthate ester has acheter Primobolan been added to the beta-hydroxyl group of the trenbolone molecule at position 17, which gives the active ingredient a depot effect compared to unesterified trenbolone, which is completely metabolized in the body within a few hours. It is based on the fact that trenbolone enanthate is biologically inactive and protected against degradation until the enzymatic cleavage of the enanthate ester. The heavier and longer the attached ester is, the slower this cleavage takes place. As a result, the half-life of the active substance is longer. Since the enanthate ester is a fairly heavy ester, trenbolone enanthate has a total active time of almost 14 days in the body. Due to the fact.
General properties trenbolone
The anabolic effect of trenbolone is usually given in the relevant steroid literature with 3 to 5 times the anabolic effect of testosterone. However, some studies also conclude that the anabolic effects of trenbolone and testosterone are approximately the same (4). So it can only be said with certainty that trenbolone is at least as anabolic as testosterone.
The anabolic effect of trenbolone is based, among other things, on a significant increase in nitrogen storage, which is approximately the same as compared to testosterone (5). This is another indication that testosterone and trenbolone have a similarly strong anabolic effect.
Another factor contributing to the anabolic effects of trenbolone are the fact that trenbolone can increase IGF-1 levels in muscle tissue by up to 200% (7, 8) and also the satellite cells of the muscles compared to IGF-1 and FGF (Fibroblast Growth Factor) significantly more sensitive (9). IGF-1 stimulates the growth of muscle cells and thus has a clear anabolic effect, while FGF stimulates the division of the satellite cells and is of crucial importance for the repair of muscle damage. In addition, trenbolone causes a significant increase in the amount of DNA within the muscle cells, which is an important prerequisite for hypertrophy (growth) of the muscle fibers (10).
With regard to the anabolic effect of trenbolone, it should also be interesting that this active ingredient increases nutrient efficiency due to its nutrient-redistributing effect (11, 12). In practice, this means that a larger proportion of the nutrients supplied are used to build and maintain muscle tissue and that fewer nutrients end up in the body's fat stores. In addition, trenbolone significantly improves the intake of minerals from food (13).
In addition to its anabolic the effect, trenbolone also has a clear strength-increasing effect, which is based on the fact that this active ingredient promotes the filling of the creatine phosphate stores in the muscle cells so that more ATP needed for muscle contraction can be produced more quickly.
The androgenic effects of trenbolone
Even though trenbolone is a very common active ingredient that has been the subject of numerous studies since the early 1960s and has been used in veterinary medicine since the early 1970s, there is still confusion as to how strong it is Trenbolone's androgenic effects really fail.
In the relevant steroid literature, one often finds the statement that trenbolone has a strong androgenic effect, which clearly exceeds the androgenic effect of testosterone and is said to be in the range of the androgenic effect of dihydrotestosterone, the strongest endogenous androgen. This view is supported by some studies that confirm that trenbolone has a 3 to a 5-fold greater affinity for the androgen receptor than testosterone (1, 2, 3).
However, a recent study comparing the androgen effects of trenbolone and testosterone in vivo (on living animals) using the so-called Herschberger assay (4) comes to the conclusion that the androgen effects of trenbolone in the androgen-sensitive tissue of the prostate are significantly less than that of testosterone fails. The result of this study also coincides with anecdotal reports from trenbolone users who report a lower potential for androgen-related side effects compared to testosterone.
At the moment it is only possible to speculate about the exact causes of the discrepancy between strong affinity for the androgen receptor on the one hand and less observed androgen effects in practice on the other hand, and further studies are required to explain this phenomenon.
In addition to its anabolic and androgenic effects, trenbolone also has a pronounced anti-catabolic effect, due to which this steroid has been observed by many bodybuilders during diet and competition preparation. In contrast to most anabolic steroids with anti-catabolic properties, which exert their anti-catabolic effect by competitively occupying the glucocorticoid receptor and thus prevent cortisol from exerting its catabolic effect on this receptor, trenbolone has practically no affinity for this receptor (14).
Nevertheless, trenbolone significantly reduces the binding of cortisol to the glucocorticoid receptor after only a few days (14), which is probably due to the fact that trenbolone reduces the number of glucocorticoid receptors in the area of the muscles. In addition, trenbolone lowers cortisol release (15) by up to 40% and significantly reduces gene expression induced by cortisol (4).
In practice, it can be observed that bodybuilders combine trenbolone with other anti-catabolic steroids such as testosterone, which exerts their anti-catabolic effects by blocking the glucocorticoid receptors. This leads to a synergistic interaction, since trenbolone reduces the cortisol release and the effect of cortisol, while testosterone prevents the remaining cortisol from exerting a catabolic effect on the glucocorticoid receptors.
Trenbolone in competitive bodybuilding
Another property of trenbolone that is valued by many competitive bodybuilders during the diet is its the fat-burning effect, which in the relevant steroid literature is usually attributed to the strong androgenic effects of trenbolone. Since trenbolone has been shown to have a significantly lower androgenic effect than previously assumed, it can be assumed, however, that its fat-burning effect is based at least in part on other mechanisms.
Studies have shown beyond a doubt that trenbolone has a fat-burning effect. Interestingly, this effect only appears when there is little or no estrogen in the body (16). This would mean that a combination of trenbolone with aromatizing steroids negates the fat-burning properties of trenbolone because aromatizing steroids increase the level of estrogen in the body. For this the reason, it can be observed in practice that competitive bodybuilders who are aware of this fact but still want to benefit from a synergy of the fat-burning effects of testosterone and trenbolone, use an aromatase inhibitor in addition to testosterone to keep estrogen levels low.
So far there has only been speculation about the exact mechanisms by which trenbolone stimulates fat burning. A presumption is related to the pronounced progesterone effects of trenbolone. Progesterone is known to increase body temperature and even cause fever at higher doses (17, 18), which is synonymous with increased thermogenesis and energy consumption. This could also explain the nighttime hot flashes and sweats, which many users of higher trenbolone doses report.
Since glucocorticoids such as cortisol significantly reduce the activity of so-called decoupling proteins (proteins that decouple the combustion of nutrients in the mitochondria from ATP production in favor of heat production) (19, 20) and trenbolone, as already mentioned, significantly reduces the release of cortisol reduced, trenbolone could indirectly increase the activity of the decoupling proteins and thereby stimulate thermogenesis.
Another possible factor is the increase in IGF-1 release in the muscles stimulated by trenbolone. IGF-1 causes, among other things, that glucose is transported to the fat cells less efficiently (21) and at the same time makes the fat cells more sensitive to lipolysis (fat burning) stimulating beta-agonists such as epinephrine, norepinephrine, ephedrine, and clenbuterol.
More muscle hardness?
In addition to its fat-burning effects, trenbolone is also known to promote definition and muscle hardness. In addition to the fact that trenbolone causes practically no estrogen-related water retention, this could also be due to the fact that this active substance, like its alpha-17-alkylated counterpart metribolone, acts as an antagonist for the aldosterone receptor (22) and thus blocks it for aldosterone. Aldosterone increases the storage of water in the subcutaneous fatty tissue, while at the same time drawing water out of the muscle tissue. This makes the muscles appear flatter and spongy.
Even though trenbolone can in principle be converted into estrogen by the aromatase enzyme, the conversion rate is in the range of less than 2% (23) and is therefore practically negligible. At the same time, however, trenbolone has a clear affinity for the progesterone receptor, which, depending on the source, is almost as strong as that of progesterone itself and can also produce a significant progesterone effect on this receptor (1, 3).
Since trenbolone is more likely to have a significantly lower androgenic effect than testosterone, trenbolone should also have a lower potential for androgen-related side effects such as acne, oily skin, increased aggression, worsening of androgen-related hair loss and male-female symptoms in comparison to testosterone. If androgen-related side effects occur, these cannot be counteracted with the help of a 5-alpha reductase inhibitor such as finasteride, since trenbolone is not metabolized by this enzyme (30).
Due to the fact that trenbolone cannot be converted to estrogen to any significant extent, estrogen-related side effects such as water retention rings, estrogen-related fat build-up, increased blood pressure or the development of gynecomastia is not to be expected when this active ingredient is used alone. It looks different when flavoring steroids are combined with trenbolone. In this scenario, the clearly pronounced progesterone effect of trenbolone comes into play. Even if progesterone alone is not able to cause estrogen-related side effects such as the development of gynecomastia (24, 25), progesterone significantly increases the estrogen effect of estrogen in certain tissue types of the body (26). In other words,
For this reason, it can be observed in practice that trenbolone users who use accompanying flavoring steroids also use an aromatase inhibitor such as Arimidex or an estrogen receptor blocker such as Nolvadex (tamoxifen). Attempts to explain that a Tren Gyno is attributed to an alleged increase in prolactin levels caused by trenbolone can be relegated to the realm of myth with a clear conscience since studies have shown that trenbolone does not influence or even lower prolactin levels (27, 28).
The strong progesterone effect of trenbolone also contributes to significantly stronger suppression of the body's own testosterone production than with exogenous testosterone and, in addition desensitizes the LH hormone receptors in the testes (29), which means that the body's own hormone production after discontinuation from Trenbolon is only very slowly getting going again. For this reason, it can often be observed that trenbolone users continue to use testosterone for a while after stopping trenbolone to reduce the influence of the effects of trenbolone on progesterone and use HCG after the end of testosterone use to sensitize the testicles to LH again.
The combination of suppressed endogenous testosterone production and the pronounced progesterone effect of trenbolone is also responsible for potency problems associated with the use of trenbolone (31), which are known in the American area under the name "Fina Dick". To counteract these problems, many users combine testosterone with trenbolone according to practical observations.
While there are some case reports in the medical literature about trenbolone-induced liver diseases (32) and an increased liver burden from this active ingredient cannot be ruled out, a statement that trenbolone is a major burden on the kidneys belongs in the realm of myths and legends. There is no evidence of such a side effect in the medical literature and an occasionally observed darkening of the urine during the use of trenbolone is only due to the brownish coloring of trenbolone metabolites that are excreted in the urine (30).
Other side effects of trenbolone include a shift in the ratio of good HDL cholesterol to bad LDL cholesterol towards bad LDL cholesterol, as well as sleep disorders and increased sweating at higher doses. The occasional cough, known as Fina Cough, which occurs immediately after a trenbolone injection and is reported in numerous American forums are less likely to be related to the active ingredient itself and more to impurities in so-called home brewing preparations.
Areas of application
In practice, it can be observed that trenbolone enanthate is used both during diet and preparation for competitions and during a mass gain. It can be observed here that longer-acting trenbolone esters such as trenbolone enanthate are used more frequently for the purpose of building up mass, whereas short-acting trenbolone acetate is preferred to longer-acting trenbolone esters during diet and competition preparation.
The use of trenbolone by endurance athletes can practically not be observed since this substance appears to have a negative impact on endurance performance for reasons not yet known.
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