A family of proteins block the release of HIV and other viruses

University of Missouri researchers have found that a family of proteins that promotes virus entry into cells also has the ability to block the release of HIV and other viruses. The study was published in the Proceedings of the National Academy of Sciences. It's a surprising finding that provides new insights into our understanding of not only HIV infection, but also that of Ebola and other viruses.

AIDS, which caused by the human immunodeficiency virus type 1 (HIV-1), is a condition characterized by progressive failure of the immune system. Today, more than one million Americans currently are living with AIDS. When HIV or any virus infects a cell, it replicates and spreads to other cells. One type of cellular protein— T cell immunoglobulin and mucin domain(Tim-1)— has previously been shown to promote entry of some highly pathogenic viruses into host cells. Now, the researchers have found that the same protein possesses a unique ability to block the release of HIV-1 and Ebola virus.

This study shows that TIM proteins keep viral particles from being released by the infected cell and instead keep them tethered to the cell surface. Scientists performed a series of experiments that revealed the protein’s ability to inhibit HIV-1 release, resulting in diminished viral production and replication.

University of Missouri researchers have found that a family of proteins that promotes virus entry into cells also has the ability to block the release of HIV and other viruses. The study was published in the Proceedings of the National Academy of Sciences. It's a surprising finding that provides new insights into our understanding of not only HIV infection, but also that of Ebola and other viruses.

AIDS, which caused by the human immunodeficiency virus type 1 (HIV-1), is a condition characterized by progressive failure of the immune system. Today, more than one million Americans currently are living with AIDS. When HIV or any virus infects a cell, it replicates and spreads to other cells. One type of cellular protein— T cell immunoglobulin and mucin domain(TIM-1)— has previously been shown to promote entry of some highly pathogenic viruses into host cells. Now, the researchers have found that the same protein possesses a unique ability to block the release of HIV-1 and Ebola virus.

This study shows that TIM proteins keep viral particles from being released by the infected cell and instead keep them tethered to the cell surface. Scientists performed a series of experiments that revealed the protein’s ability to inhibit HIV-1 release, resulting in diminished viral production and replication.

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