A novel murine model for neuron disease

As the hot summer comes, many patients with diabetes find that, when the weather is becoming hotter, the blood sugar level will decrease, so now is the best time for treatment of diabetes mellitus. Therefore, adjustment of therapy may be necessary according to the doctor's advices. Today is still a topic of diabetes.

Type 2 diabetes (T2D) are known to manifest in adults, while type 1 diabetes (T1D) typically manifests in children and adolescents with a certain genetic background and accounts for 5-10% of patients with diabetes. The pathogenesis of type 1 diabetes is generally believed because of cell-mediated autoimmune destruction of insulin-producing?-cells, which leads to insulin insufficiency and insulin resistance. Although insulin administration has significantly improved the life style of T1D patients, microvascular and macrovascular complications and end-stage renal disease. It is necessary to explore more effective treatment modalities for T1D.

Since intrinsic defects in the individual development appear to collectively contribute to the type 1 diabetes, modulation of the epigenome of the immune system and the endocrine pancreas holds promise to provide robust protection against T1D, and thus has been used as a new therapy strategy. Further details will be discussed in next post.

Epigenetics provide a mechanism by which external factors can produce a variety of phenotypic variations with identical genotypes, including Type 1 Diabetes.

As indicated in previous study results, analysis of genome wide methylation patterns is likely to identify genes that are repressed in T1D patients by hypermethylation at the gene promoters. Thus, some FDA-approved drugs, such as azacytidine and decitabine, may has good efficacy for T1D treatment by inducing hypomethylation and gene transcription.

Besides, some epigenetic drugs has been found to be involved in the treatment study of Type 1 Diabetes. For example, Tsa, a small molecule HDAC inhibitor, induces long-term protection against T1D in NOD mice, which is accompanied by diminished inflammatory cellular infiltration of the pancreas, preservation of?-cell mass, restoration of normoglycemia, and glucose-induced insulin release by?-cells. Thus, this implies that modulation of the immune system by epigenetic mechanisms may exert protective effects against T1D by increasing IFN-?, which has pluripotential effects on immune system and the ability to cross-regulate other signal transduction pathways in islet cells.

Presumably, the incidence of Type 1 Diabetes will double in children by 2020 in developed countries, thus, it is urgently needed to control diabetes occurrence.

Numerologist Warda is hooked on OG-L002 fishing, collecting. And lastly her encouragement comes from socializing along with her companions.