BPC-157 in summary

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is a peptide chain consisting of 15 amino acids. It is considered synthetic because this particular sequence does not exist in nature. It is derived from a protective protein found in the stomach.

Researchers have conducted numerous rodent studies on BPC-157 that show it has protective effects extending beyond the stomach and intestinal tract. BPC-157 has been shown to benefit ulcers in the stomach, intestinal damage such as fistulas and inflammatory disorders, bone and joint healing and growth rates, and organ damage. It also has some influences on the brain. Researchers have observed marked protective effects when BPC-157 is administired to rats alongside a research toxin or damaging surgical procedure.

More research is needed to clarify whether BPC-157 has multiple mechanisms of action, but current research suggests BPC-157 influences several growth factors usually involved in angiogenesis (the production of blood vessels) and other factors involved in regeneration following damage.

bpc 157

shows promise, but human studies are needed to demonstrate that these benefits extend beyond research animals.

The majority of studies on BPC-157 are done on rats given injections of the supplement. While BPC-157 is a stable peptide, peptides are a group of compounds that are normally poorly absorbed after oral supplementation, so researchers use injections in rodent studies instead. Furthermore, there is no human evidence for BPC-157 and the majority of the research has been conducted by a single research group. Due to its synthetic nature, there may be legal issues associated with the sale of this supplement in certain regions and it may be banned by some sport organizations.

BPC 157 may serve as a novel mediator of Robert’s cytoprotection, involved in maintaining of GI mucosa integrity, with no toxic effect. BPC 157 was successful in the therapy of GI tract, periodontitis, liver and pancreas lesions, and in the healing of various tissues and wounds. Stimulated Egr-1 gene, NAB2, FAK-paxillin and JAK-2 pathways are hitherto implicated. Initially corresponding beneficial central influence was seen when BPC 157 was given peripherally and a serotonin release in particular brain areas, mostly nigrostriatal, was changed. BPC 157 modulates serotonergic and dopaminergic systems, beneficially affects various behavioral disturbances that otherwise appeared due to specifically (over)stimulated/damaged neurotransmitters systems. Besides, BPC 157 has neuroprotective effects: protects somatosensory neurons; peripheral nerve regeneration appearent after transection; after traumatic brain injury counteracts the otherwise progressing course, in rat spinal cord compression with tail paralysis, axonal and neuronal necrosis, demyelination, cyst formation and rescues tail function in both short-terms and long-terms; after NSAIDs or insulin overdose or cuprizone encephalopathies were attenuated along with GI, liver and vascular injuries.

The discovery of the brain-gut axis belongs to the seminal Pavlov’s work, his sham-feeding of dogs with gastric fistula, and the role of vagus nerve in the control of gastric acid secretion [1]. This has been further proven with the Selye’s discovery that agents, although very diverse, always elicit the same neuroendocrine response and that gastroduodenal ulcers are the last segment of morphologic triad: hypophyseal-adrenocortical stimulation, thymo-lymphatic involution and gastroduodenal ulceration [2]. However, the current view of the brain-gut axis relies on the extensive evidence carried out by many groups in the late 1980s (most of them were Selyes’ students) showing that the most potent effect of many peptides (i.e., bombesin, thyrotropin-releasing hormone, corticotropin-releasing factor, neurotensin) is the modification of gastrointestinal (GI) functions. The most prominent action of these peptides on gastric lesions [3-10] appears when applied within the specific hypothalamic and brain stem sites or into the cerebrospinal fluid [11]. Since the brain-gut axis purports an interaction between the brain and the gut, and vice versa [12], this concept also implies neurotransmitters and/or peptidergic growth factors, native in GI tract which have strong anti-ulcer potency and thus would from periphery beneficially affect CNS disorders as well. For the therapy purpose this means a harmony that has to be established between the brain and the gut. Supporting is the research providing evidence that the gut–brain axis, as a bidirectional neurohumoral communication system in the human body, also function as a pathway for the gut microbiota to modulate brain function of its host

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