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WHAT ARE THE SIDE EFFECTS OF PAIN MEDICATIONS?NSAIDs

All NSAIDs come with the risk of gastrointestinal ulceration and bleeding. A newer class of anti-inflammatories, the COX-2 inhibitors, was developed to reduce this risk. It did not, though, eliminate it. In fact, another major issue emerged with these drugs: the possibility of severe and deadly vascular problems with long-term use, including heart attack and stroke.

Acetaminophen

Most users of acetaminophen experience few, if any, side effects. But the drug can cause liver damage, especially when taking too much or if taken with alcohol.

Opioids

Opioid analgesics commonly cause drowsiness, dizziness, and respiratory depression. However, these side effects usually disappear with continued use. However, constipation, another common side effect, tends to persist. In addition, opioid use may lead to addiction or dependence. Other possible side effects of opioid analgesics include:

Euphoria, dysphoria, agitation, seizures, hallucinationsLowered blood pressure and heart rateMuscular rigidity and contractionsNausea and vomitingNon-allergic itchingPupil constrictionSexual dysfunctionUrinary retentionMixed opioid agonist-antagonists

Patients can experience symptoms of opioid withdrawal if a straight opioid analgesic, such as morphine, is taken at the same time as an opioid agonist-antagonist drug. Some of these medications include pentazocine (Talwin Nx, Talacen, Talwin Compound), butorphanol, and nalbuphine (Nubain).

Muscle relaxants

The main side effect of muscle relaxants is drowsiness. This may be how they work to "relieve" pain. In addition, carisoprodol (Soma) use may lead to dependence because in the body it is converted into a drug similar to barbiturates; cyclobenzaprine (Flexeril) can cause dry mouth, constipation, confusion, and loss of balance; methocarbamol (Robaxin) discolors the urine to green, brown, or black; both metaxalone (Skelaxin) and chlorzoxazone (Parafon Forte, DSC) should be used with caution in those with liver problems.

Anti-anxiety agents

Anti-anxiety drugs also carry the risk of sedation, particularly if combined with certain other medications (such as opioid analgesics) or alcohol. Other possible side effects include psychological changes, headache, nausea, visual problems, restlessness, and nightmares. Chest pain and heart pounding are also possible.

Antidepressants

Some of the antidepressants used for pain relief are the older tricyclics. These come with numerous side effects classified as anticholinergic, including dry mouth, difficulty urinating, blurred vision, and constipation. Other possible side effects include lower blood pressure, fast heartbeat, palpitations, weight gain, and fatigue.

A few of the newer antidepressants also reduce pain -- and with less risk of anticholinergic issues. Still, the serotonin norepinephrine reuptake inhibitors (SNRIs) may cause the following common side effects:

AnorexiaAstheniaConstipationDizzinessDry mouthEjaculatory difficultiesHeadacheInsomniaNauseaNervousnessSweatingAntiseizure agents

Side effects associated with the anticonvulsants used for pain management commonly disappear over time. They include dizziness, drowsiness, and swelling of the lower extremities.

Corticosteroids

In general, short-term and/or low-dose corticosteroid use results in few side effects. But taking corticosteroids long-term can result in severe side effects, including:

Adrenal insufficiency -- a condition in which the body cannot adequately respond to physical stressAtherosclerosisBone deathCataracts and glaucomaElevated blood pressureElevated blood sugarFluid retentionGastrointestinal bleedingMood changesOsteoporosisSuppression of the immune systemTrouble sleepingWeight gainDamage to local tissues

Take this medicine according to doctor’s prescription. Do not crush or chew the drug, but instead swallow it with your mouth. It usually is 1 to 3 times a day.