Case Study Shows CAR-NK Therapy Restarted Life of 66-Year-Old

The cancer recurs repeatedly, and the side effects of high-dose chemotherapy are unbearable. It destroys cancer cells and damages healthy cells at the same time. The treatment can be a torture to cancer patients.

J.C.Cox is one of them, who suffered from non-Hodgkin's lymphoma, and received 12 years of chemotherapy. Therefore, when a new attempt appeared, JC did not hesitate to make a choice and became one of the few people in the world to receive CAR-NK cell therapy.

Similar to the prestigious CAR-T (chimeric antigen receptor T cells) cell therapy that has been approved for marketing, the new clinical trial added CAR to natural killer cells (NK cells), making these cells to hide in the body to more accurately identify and kill cancer cells. Thanks to the emergence of CAR-NK cell therapy, JC's health condition improved after only 30 days of treatment. In April 2018, JC's cancer was completely relieved.

The results of this study were also published in NEJM (New England Journal of Medicine) in March 2020. Of the 11 patients in the clinical trial, 8 (73%) showed responded to CAR-NK treatment, and 7 patients, including JC, were in complete remission, which means that all cancer symptoms and signs have disappeared. Although this is only a small-scale research, these promising and exciting results give more patients in need an effective new treatment option.

NK cells are the best killers for virus-infected cells and tumor cells. They have a natural killing ability as well as the function of immunological memory. They can quickly start the second attack under the stimulation of the same antigen, exerting a stronger immune response. In the fight against cancer, NK cells are also the most effective broad-spectrum anti-cancer cells. The anti-cancer mechanisms of NK cells is very diverse, and they also have a killing effect on almost all common types of cancer cells, including lung cancer, breast cancer, liver cancer, lymphoma, and so on. More importantly, NK cells have a wide range of sources and can be extracted from healthy people or umbilical cord blood.

NK cells are an important member of the human innate immune system. They are good at identifying and destroying cancer cells at an early stage. However, cunning cancer cells can develop ways to evade the immune system. By modifying NK cells, they can be equipped with a bullet. The "CAR" can expand its natural anti-cancer ability and make natural killer cells more veritable. Multiple doses of CAR-NK cells can be produced from one donor and can be used to treat multiple patients. Due to their unique characteristics, CAR-NK cells may be manufactured, frozen and stored in advance, and immediately provided to anyone who needs them.

In general, CAR-NK is known for its wide range of sources, easier access, and wide range of killing tumors, and it is expected to become a more effective, economical and safer treatment for all cancer patients. As the leading biotech company focusing on cell therapeutics development services, Creative Biolabs masters the most advanced CAR technology, and is capable of offering a broad range of CAR-NK development services, including CAR engineered T cell biomarker identification and selection, design, construction, and analysis.

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