Synthesis of Custom Peptides Boosting Drug Development

Presently, the pharmaceutical sector is synthesizing peptides through multiple processes, on account of technological advancements. In earlier times, peptides were produced with the help of natural sources. For instance, adrenocorticotropic hormone (ACTH) was developed from porcine and bovine pituitary, and insulin was derived from bovine and canine pancreas. These manufacturing processes were time consuming and resulted in low production. However, with innovations in technology, biopharmaceutical companies have started creating synthetic peptides like vasopressin, leuprorelin, oxytocin, and octreotide with the help of solid-phase peptide synthesis (SPPS), hybrid and recombinant technology, and solution-phase peptide synthesis (SPS) technologies.

Moreover, the surging participation of private and public research institutes in synthetic biology research will accelerate the customized peptide synthesis market at a CAGR of 6.4% during 2019–2024. The market stood at $268.8 million in 2018, and it has the potential to reach $390.0 million by 2024. The increasing participation of research entities will amplify the funding for the development of advanced and innovative bio-based products, to deal with the global health challenges. These research and development (R&D) activities are essentially aimed at producing better drugs for the treatment of chronic diseases.

Apart from pharmaceutical and biotechnology companies and academic and research institutes, contract manufacturing organizations (CMOs) and contract research organizations (CROs) also utilize peptides in large quantities. These entities require a wide range of reagents and equipment to synthesize peptides for antibody production, enzyme profiling, drug discovery, disease research, and biomarker discovery. The reagents utilized by them for the synthesis of peptides include precipitation agents, additives, substrates, and buffers, while the advanced platforms being used for the purpose include the PepTrend system.

Geographically, North America synthesized the highest volume of customized peptides in 2018 due to the rising utilization of these biopharmaceuticals for preparing monoclonal antibodies, performing disease research, and discovering drugs. Moreover, the escalating funding from governments for peptide research and increasing incidence of chronic diseases in the region have pushed the demand for customized peptides. According to the Centers for Disease Control and Prevention (CDC), 6 in 10 adults in the U.S. are living with some chronic disorder. Additionally, CDC states that the country registers at least one cardiovascular disease (CVD)-related death every 36 seconds.

According to P&S Intelligence, the Asia-Pacific customized peptide synthesis market will exhibit the fastest growth in the foreseeable future. This will be due to the high-volume usage of peptides in drug discovery, constant technological innovations, hefty R&D funding, and low cost of raw materials in the region. Drug manufacturers in APAC countries are racing to meet the growing requirement for peptide-based drugs to treat chronic diseases. Additionally, new research findings in the region will offer lucrative opportunities for the discovery of peptide-based drugs in the coming years.

Such increasing research activities across the world have encouraged key biopharmaceutical companies, such as JPT Peptide Technologies GmbH, GenScript Biotech Corporation, New England Peptide Inc., Thermo Fisher Scientific Inc., Rockland Immunochemicals Inc., Bachem AG, AAPPTec LLC, INTAVIS Bioanalytical Instruments AG, and Advanced ChemTech, to develop new peptide-based products. For instance, Biotage AB introduced its new Alstra remote software in September 2018. The software allows users to program the peptide synthesis setup offline, eventually import peptide sequences, and then carry out the synthesis on Initiator + Alstra.

Thus, the continuous technological advancements and hefty investments in R&D will lead to a significant rise in the peptide designing and synthesizing activities in the coming years.

This study covers

• Major factors driving the market and their impact during the short, medium, and long terms
• Market restraints and their impact during the short, medium, and long terms
• Recent trends and evolving opportunities for the market participants
• Historical and the present size of the market segments and understand their comparative future potential
• Potential of on-demand logistics services, so the market players make informed decisions on the sales of their offerings
• Competitive scenario of various market segments across key countries in several regions for uncovering market opportunities for the stakeholders
• Major players operating in the market and their service offerings

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