Benefits Of Elevated Plus Maze, Pelletizing Machine & Plethysmometer In Pharmacitical Industry

Elevated Plus Maze -

The Elevated Plus Maze test is used to assess anxiety-related behavior in rodent models of CNS disorders. The Elevated plus maze apparatus consists of a "+"-shaped maze elevated above the floor with two oppositely positioned closed arms, two oppositely positioned open arms, and a center area.

The VJ Instruments Elevated plus maze is manufactured using high-end non-reflective material and is available for rats or mice. The maze is available in any custom color.

One of the tests that are most frequently used to gauge anxiety-like behavior in the elevated plus maze test. The test is based on the natural aversion of mice to open and elevated areas, as well as on their natural spontaneous exploratory behavior in novel environments.

Elevated plus maze in pharmacology -

The elevated plus maze is a commonly used behavioral assay for mice, and it has been validated to describe the brain areas and mechanisms behind anxiety-related behavior as well as to evaluate the anti-anxiety effects of pharmaceutical treatments and steroid hormones.

How is an elevated plus maze used?

The mouse elevated plus maze is positioned on the table (but could also be placed on the floor) such that there are similar levels of illumination on both open and closed arms. The legs of the maze are adjusted so that the maze is perpendicular to the ground and each arm is level.

Pelletizing Machine -

Pelletization is an agglomeration process that converts fine powders or granules of bulk drugs and excipients into small, free-flowing, spherical, or semi-spherical units, referred to as pellets.

For handling or metering purposes, Pelletizing Machine create a pellet with a constant size, shape, and weight. Pelletizing machinery is necessary for the production of a variety of products, including polymers, catalysts, chemicals, and feedstock. The pellet form offers several processing advantages over other forms.

Basically, the purpose of pelleting is to take a finely divided, sometimes dusty, unpalatable, and difficult-to-handle feed material and, by using heat, moisture, and pressure, form it into larger particles.

Function of pelletizing machine -

It's common for the pelletizing device to be connected to an extruder or a gear pump in order to transform the product into pellets of various shapes and sizes. Compared to other forms, the pellet form has a number of processing advantages

Advantages -

• The palatability of the feed is increased.
• Reduced dust.
• Improves palatability.
• The segregation of ingredients in a mixing, handling, or feeding process is prevented.
• By breaking down the starches, the heat produced during conditioning and pelleting makes the feedstuffs easier to digest.

Disadvantage -

• Higher processing costs, the use of a binder, and the required drying step results in higher processing costs with a pelletizer plant compared to compaction granulation.

Plethysmometer -

The Plethysmometer (Paw Edema) test is used to assess how well anti-inflammatory drugs are working to control epidemic symptoms. When in use, the paw is dipped into water that is housed in a unique water cell, the resistance of which is altered by the animal's paw.

The Digital plethysmometer is a valuable tool for detecting inflammation by tracking changes in tiny paw volume. When a rat or mouse paw is inserted into the apparatus, it monitors minute volume changes brought on by water displacement.

The Digital Water plethysmometer is intended to be a very practical tool for measuring minute volume changes. This test is frequently used to track the development of an experimentally generated inflammatory response in rodents and to check for potential anti-inflammatory or anti-oedema characteristics in pharmaceuticals.

The volume transducer is essentially made of two Perspex tubes joined together, each filled with a platinum electrode and a conductive fluid. A stand (included) that may be positioned over the control unit supports the entire system.

Features of plethysmometer -

• Simple user interface
• Water loss correction provision for each reading
• Image based technology
• Foot switch (USB foot switch)
• User friendly computer software

Pharmaceutical instruments which are mostly sed in food and many other industries.