Advanced Preclinical Models for Smarter Drug Discovery | ZEFIT

ZEFIT is revolutionizing early-stage drug discovery by using zebrafish, a scalable in-vivo model, to streamline compound safety, efficacy, and medical potential evaluations, reducing reliance on animal testing and enabling researchers and pharmaceutical companies to develop novel therapeutics with precision.

ZEFIT uses genome editing to create zebrafish disease models, ensuring precision and relevance to human conditions. AI-powered systems streamline testing, reduce variability, and shorten development cycles. ZEFIT robust database enables data-driven compound safety predictions.

Key Advantages for Disease Research & Drug Discovery,

• Genetic similarity to humans

Zebrafish, due to their high genetic homology with humans, are ideal for studying diseases in pharmacology and developmental biology due to their unique genetic makeup.

• Efficient for genetic studies

The high fertility, external fertilization, and fast growth of these organisms make them ideal for large-scale genetic and cancer research, as well as drug discovery.

• Fast and scalable screening

Zebrafish is ideal for high-throughput screening of genes and compounds due to its small size and easy handling.

• Clear developmental observation

Transparent embryos enable clear developmental observation, enabling easy visualization of organ development and detection of disease traits.

• Live brain imaging

Live brain imaging utilizes transparency and fluorescent tools to monitor neuron activity and brain function in real-time.

• Rapid development

Zebrafish rapidly develop, forming larvae in 72 hours, juveniles by 30 days, and adults by 90 days, and forming a blood-brain barrier by 72 hours post-hatching.

• Ideal for disease modeling

The easy genetic manipulation of this material is ideal for disease modeling, as it allows for real-time tracking of disease progression and understanding of its mechanisms.

• In vivo disease screening

Zebrafish is a valuable tool for evaluating complex biological responses due to its ability to perform integrated physiological testing on drugs.

• Integrated physiological testing

ADME-Tox testing utilizes functional organs like the liver and kidney to provide insights into drug metabolism, enabling the translation of results to mammalian models.

• Drug metabolism insights

Zebrafish is being utilized for the rapid and cost-effective screening and in vivo evaluation of potential drug candidates.

• Accelerated drug development

CRISPR-Cas9 is a simple gene editing tool that enables the creation of custom disease models for study quickly.

• Simple gene editing

Zebrafish, despite their structural differences from mammals, share similar brain systems and are useful for studying movement, memory, and behavior through behavioral testing.

• Behavioral testing ready

Zebrafish, despite their structural differences from mammals, share similar brain systems and are useful for studying movement, memory, and behavior through behavioral testing.

If you are looking for a drug discovery platform, you can find them at ZEFIT.

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