Jerry Carter

In preclinical models of SCLC, CD47 blockade was found to be effective in enhancing the local antitumor effects of radiotherapy. "Radiotherapy in combination with CD47 blockade elicits a...

Alzheimer's disease is a neurodegenerative disease with insidious onset and progressive development, of which the clinical features are mainly cognitive impairment, abnormal mental behavior, and...

PROTAC is a novel type of drug that is different from antibodies and traditional small molecule inhibitors, consisting of a linker and two warheads. One end of the PROTAC molecule binds to the target...

Craig Crews et al. presented the notion of PROTAC (Proteolysis Targeting Chimera) in 2001 to reduce protein levels instead of blocking protein function by exploiting the body's naturally occurring...

PROTAC-mediated protein degradation is UPS-dependent, and the formation of the POI-PROTAC-E3 ternary complex is a prerequisite for the successful degradation of the target protein. Currently, the...

The Dana-Farber Cancer Institute utilized SWOT analysis to targeted protein degradation drug development to better evaluate the approach's strengths, weaknesses, opportunities, and threats.SWOT...

"Intratumourally injected alum-tethered cytokines elicit potent and safer local and systemic anticancer immunity", published by a team of researchers from the Massachusetts Institute of Technology...

Hotspot in the morning of July 19—"Mars rainbow candy is accused of causing DNA changes."News reported that American consumers recently filed a lawsuit against Mars Inc. in California state court...

A few days ago, Arvinas, which is committed to developing targeted protein degradation therapies, announced at the American Association for Cancer Research (AACR) annual meeting the molecular...

The latest clinical trial data on the allogeneic stem cell therapy VX-880 for type I diabetes was just revealed by Vertex, one of the world's pharmaceutical giants. The patient's insulin production...

Since they were originally explored in animal models in the 1960s, antibody-drug conjugates (ADCs) have seen many booms. The initial ADC clinical studies took place in the 1980s, and Mylotarg, the...

SIRP?-Fc fusion proteinTTI-621, the SIRP-Fc fusion protein, is an immune checkpoint inhibitor that targets CD47. TTI-621 improves CD47 blockage through attaching to the macrophage Fc receptor (FcR...

CD47 is a transmembrane protein that regulates a wide range of physiological and pathological functions in the body. CD47 expressed on tumor cells interacts with signal-regulated protein alpha (SIRP...

In a recent study published in Nature Communications entitled "Maladaptive positive feedback production of ChREBP? underlies glucotoxic?-cell failure", scientists from the Icahn School of Medicine at...

Aging is the progressive decline in organismal fitness that occurs over time, leading to tissue dysfunction and disease. At the cellular level, senescence is associated with functional decline...