Jerry Carter

Each year, bacterial infections kill hundreds of thousands of people, primarily in low- and middle-income countries. Given that only a few antibiotics have been approved during the last 50 years, the...

The flexible design of nanomaterials confers better specific immune responses to nanovaccines, mainly due to the unique drug/antigen delivery properties of nanomedicines and nanomodulation of...

Vaccines are an unparalleled medical milestone, which have saved countless lives by harnessing the human immune system. Vaccination remained the most effective means of defense during the COVID-19...

Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are adult-onset progressive neurodegenerative diseases that belong to the same disease spectrum. In ALS, the motor...

MYC mutations are among the most common in human cancers and can not only cause cancer in normal cells but also help cancer cells escape the immune response. MYC protein, on the other hand, is a...

In recent years, non-alcoholic fatty liver disease (NAFLD) has become a growing epidemic with the unhealthy lifestyle of people.A significant number of patients with non-alcoholic fatty liver disease...

On July 18, a case of polio was discovered in Rockland County, New York, the first case in the United States in nearly a decade. A statement from the New York State Department of Health said the case...

Novel cytotoxic drugsNew cytotoxic drugs have been developed to target cancer cells with low antigen expression or resistance to auristatins or maytansinoids. For this purpose, PBD dimers have been...

Antibody-drug conjugate (ADC), a compound that connects a cytotoxic small-molecule drug to a monoclonal antibody via a rationally established linker, which selectively delivers an efficient cytotoxic...

Kadcyla and second-generation non-cleavable linkersAlternative linker design methodologies are still under development. Immunogen discovered a very powerful ADC by an accidental discovery. The lysine...

As viruses mutate at breakneck speed, traditional antibody therapies are often caught in a game of catch-up. But a recent breakthrough published in Nature Communications (May 2025) might just tip the...

Genotoxic Cancer Therapy (GCT) kills cancer cells by causing extensive DNA damage. Among them, Radiation therapy (RT) is the most widely used genotoxic cancer therapy. When radiation passes through...

Sugar is a direct source of sweetness that not only enhances the flavor of food but also serves as a source of energy for the body. Sugar is used in everyday life to give us a "sweet" feeling, whether...

Glycosylation is a sophisticated type of post-translational modification that impacts over 50% of cellular proteins and is a critical regulator of many eukaryotic processes. Aberrant glycosylation is...

T cells in tumor tissue are critical for both tumor immunosurveillance and elimination. CD8+ tumor infiltrating lymphocytes (TILs) can be used in pericyte therapy and are key targets for immune...