Iontox Biotechnology

The initial stages of drug discovery research, which include the identification of a relevant biological target and a viable lead compound with therapeutic potential, play a crucial role in the...

A metabolic stability assay is a critical in vitro screen often listed under the category of services known as ADME. Many compounds that show promise with hitting their intended pharmaceutical target...

The Caco-2 permeability assay has become the gold standard in vitro method to assess a test compound’s readiness for oral dosing.Why to Choose The Caco-2 Permeability Assay?Solubility and intestinal...

Studying the ADME properties (i.e., absorption, distribution, metabolism and excretion) of a drug candidate gives investigators critical safety and efficacy data needed when applying for the FDA IND...

Cytochrome P450 proteins are significant drug metabolizing enzymes. For pharmaceutical companies developing new compounds, the evaluation of CYP induction is a critical step in assessing drug safety...

It is important to understand the induction potential of your drug candidate for understanding drug safety. CYP induction assays assess the potential for up-regulation of cytochrome P450 enzymes as a...

In the early phases of drug discovery determination of metabolic stability of new chemical entities is an important step, since it influences pharmacokinetic properties of therapeutic compounds.In the...

Gaining data on if therapeutic compounds are toxic to cells (cytotoxicity) is a critical first step to understanding the long term viability of a set of compounds in a drug discovery program. If a...