Reduce 15 mg Mechanism of action

There are a variety of weight loss supplements like fat burners, metabolism boosters, appetite suppressants and thyroid supplements.

Anti obesity drugs suppress the appetite, increase the metabolism of the body and help to absorb nutrients in food. There are certain creams and gel, which penetrate into the skin and dissolve body fat. Diuretics promote urination. It eliminates excess water beneath the skin. It also supplies electrolytes to maintain muscle fullness.

Each capsule of Reduce 15mg contains Sibutramine 15mg which belongs to the category of appetite suppressant.

Mechanism of action:

It inhibits reuptake of norepinephrine, serotonin and dopamine. It may stimulate satiety center in brain, causing appetite suppression. Inhibits reuptake of Serotonin nor adrenaline and to a lesser extent, dopamine in Vivo and in vitro M1 and M2 Metabolite are pharmacologically active and are up to about 100-fold more potent than reuptake inhibitors of sibutramine has no effects on dopamine receptors, some thermogenic activity is evident at doses of 10mg apparent low abuse potential in humans. Reduce (Sibutramine) produce its therapeutic effect by Norepinephrine, Serotonin and dopamine reuptake inhibition.

Reduce reaches maximum therapeutic concentration in 1.2hrs. Food delays the absorption by 3hrs. Approximately 77% of the single oral dose is absorbed. Steady state reached within 4days. Reduce (Sibutramine) is extensively bound and is rapidly and extensively distributed into tissue. It undergoes extensive first pas metabolism and is primarily by cytochromep4503A4 isoenzyme. Approximately 85% of the drug eliminated through urine.

Indications: obesity, including weight loss and maintenance of weight loss; not for pregnancy and pediatric patients, hypersensitivity, patients receiving MAO inhibitors, anorexia, nervosa, patients taking other centrally acting appetite suppressant drug.

Reduce 15 mg should not be taken with MAO inhibitors and drugs that may raise blood pressure or cause heart rate. It should not be taken along with ephidrine, phenyl propanolamine.

Adverse Effects or side effects of Reduce 15 mg include: Dry mouth, anorexia, constipation, insomnia and dizziness.

Special Precautions: Monitor BP regularly when prescribing sibutramine.

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