In 2016, a genome-wide sequencing of genetic factors for Alzheimer's disease identified mutations in protein kinase C (PKCα) that were associated with the disease. Among these, the M489V mutation was...

Tumor cells can avoid immune detection and assault via mechanisms such as the production of immunological checkpoint ligands. In addition to PD-1/PD-L1, tumor cells produce CD47, which prevents...

Inactivation of the tumor suppressor genes tumor protein p53 (TP53) and cell cycle protein-dependent kinase inhibitor 2A (CDKN2A) usually occurs early in the tumorigenesis of the gastroesophageal...

Recently, scientists at the University of Pittsburgh have deciphered the mechanism by which cancer cells resist chemotherapy and the key protein Xkr8 in it, and have developed an anti-cancer...

Tumors with brain metastases often have a poor survival prognosis, including patients with a variety of high-risk pediatric tumors, such as high-risk neuroblastoma. In addition to the currently used...

Many researchers, clinicians, and patients demand accurate and speedy detection of various tumors utilizing a non-invasive or minimally invasive technique. However, we did not previously have adequate...

In a biological context, reactive oxygen species (ROS) are natural byproducts of normal oxygen metabolism and play an important role in cell signaling and homeostasis. Excess reactive oxygen species...

There is a group of "old but immortal" cells in our body, namely senescence cells that have a unique phenotype, i.e. they are not productive but also refuse to "give way", not only preventing tissue...

Cancer vaccines have shown clinical promise in driving tumor-reactive cell activation, proliferation, and effector functions. Cancer vaccine therapy, on the other hand, has not been successful in...

A major study led by Professor Jennifer Doudna, a pioneer in the field of gene editing, has recently been published online in the leading academic journal Cell, and has attracted the attention of many...

When we go to the hospital or have a medical checkup, we basically have a blood test to get blood biochemical indicators like blood glucose, blood lipids, liver, and kidney function. These indicators...

In preclinical models of SCLC, CD47 blockade was found to be effective in enhancing the local antitumor effects of radiotherapy. "Radiotherapy in combination with CD47 blockade elicits a...

There is mounting evidence that the enzyme MAPK4 is involved in cancer growth and resistance to specific therapies. Researchers from Baylor College of Medicine and other institutions discovered that...

The current diagnostic criteria for SSD place a greater emphasis on patient behavior assessment and frequently involve patient self-assessment, which is very subjective and not helpful for early...

Yu Jun's team from The Chinese University of Hong Kong published a paper in Gut (IF=32) titled "Cigarette smoke promotes colorectal cancer through modulation of gut microbiota and related metabolites...